Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health ThreatReview Published on 2023-04-102023-06-09 Journal: Viruses [Category] Fulltext, 원숭이두창, [키워드] Africa antivirals DNA Epidemic immunization Monkeypox virus Poxviridae vaccination. [DOI] 10.3390/v15040937 PMC 바로가기 [Article Type] Review
Development of a sensitive, multi-assay platform to monitor low levels of HBV DNA and pgRNA in patients with chronic hepatitis B virus infectionArticle Published on 2023-01-012023-06-12 Journal: Journal of virological methods [Category] B형 간염, [키워드] DNA HBV pgRNA. Total nucleic acid [DOI] 10.1016/j.jviromet.2022.114640 PMC 바로가기
Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumoniaArticle Published on 2022-12-132023-06-20 Journal: Immunity [Category] Fulltext, MERS, [키워드] Actin COVID-19 Degradation DNA DNase I histone Inflammation NETs proteomics sepsis. [DOI] 10.1016/j.immuni.2022.11.007 PMC 바로가기
Can torque teno virus be a predictor of SARS-CoV-2 disease progression in cancer patients?Article Published on 2022-12-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 치료기술, [키워드] analysed association Can Cancer cancer patient Cancer patients clinical manifestation Control control subjects controls correlation COVID-19 death deficiency demonstrated detectable died DNA immune system indicated Infection Nasopharyngeal swab outcomes patients with SARS-CoV-2 previous study progression Retrospective study SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 RNA SARS-CoV-2-positive patients significantly lower statistically significant subjects survival rate torque Torque teno virus. Viral load virus was related [DOI] 10.1016/j.jiac.2022.08.015 PMC 바로가기
Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA virusesArticle Published on 2022-11-072022-11-16 Journal: EMBO Reports [Category] SARS, 변종, [키워드] Antiviral approach cell line Complexes CRISPR DDX42 DDX42 DEAD-box RNA helicase Depletion DNA dominant-negative elements expression Helicase HIV-1 HIV-1 infection identify immunoprecipitation in vitro increase Infection inhibit inhibitor Interaction intrinsic intrinsic immunity LINE-1 mutant overexpression Perspective primary cells Replication restrict reverse transcription ribonucleoprotein RNA RNA virus RNA viruses RNA-seq analysis SARS-CoV-2 target cells viral infections viral inhibition. viruses [DOI] 10.15252/embr.202154061 PMC 바로가기
One-step colorimetric isothermal detection of COVID-19 with AI-assisted automated result analysis: A platform model for future emerging point-of-care RNA/DNA disease diagnosisResearch article Published on 2022-11-012022-10-05 Journal: Talanta [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] Accuracy Analysis analyzed approach automated Colorimetric RT-LAMP Complete Concordance COVID-19 COVID-19 testing cycle threshold Detection limit diagnosis of COVID-19 Disease diagnosis DNA downstream ENhance exhibited faster feasibility Interpretation isothermal LAMP-DETR limit machine learning majority observation offer pandemic pathogen performed Perspective platform point-of-care RT-LAMP RT-qPCR SARS-CoV-2 sensitivity specificity [DOI] 10.1016/j.talanta.2022.123375 [Article Type] Research article
Electrochemiluminescence resonance energy transfer biosensing platform between g-C3N4 nanosheet and Ru-SiO2@FA for dual-wavelength ratiometric detection of SARS-CoV-2 RdRp geneArticle Published on 2022-11-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amplification binding affinity Clinical diagnosis coronavirus Detection sensitivity disease DNA ECL Electrochemiluminescence energy transfer limit of detection multifunctional platform probe RdRp gene RdRp gene biosensor g-C(3)N(4) nanosheets. RET SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 virus ssDNA syndrome target gene Treatment unique was used [DOI] 10.1016/j.bios.2022.114580 PMC 바로가기
Diagnosis of monkeypox virus – An overviewReview Published on 2022-11-012023-06-09 Journal: Travel medicine and infectious disease [Category] Fulltext, 원숭이두창, [키워드] Diagnosis DNA Laboratory Monkeypox polymerase chain reaction virus. [DOI] 10.1016/j.tmaid.2022.102459 PMC 바로가기 [Article Type] Review